CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
DK Metcalf could pose a major big-play threat to Tennessee's injury-challenged corner rotation.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
Ja'Marr Chase should keep rolling against a Colts secondary with poor boundary corner personnel.
The Indianapolis secondary is weakest on the boundary and downfield, where Mike Evans is at his best.
Rhamondre Stevenson is the centerpiece of a broken offense, and this should be one of his better weeks thanks to Sunday's matchup with another last-place team.
Playing at home and against the Bears, the Week 11 setup couldn't be much easier for Amon-Ra St. Brown.
DeAndre Hopkins should be able to get rolling against a struggling and injured Tampa Bay corner rotation.
Nico Collins and Tank Dell should come roaring out of the bye week against a battered and weak Carolina secondary.
Dan Marcus highlights several rookie IDPs who have impressed so far this season, starting with JuJu Brents in Indianapolis.
The Vikings face a simple reality Sunday: either Jordan Addison has a strong game, or the Minnesota passing game falls apart.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
The Dolphins are looking to bring a shootout to the Bills, but Stefon Diggs is prepared to shoot back against Miami's questionable pass defense.
Christian Kirk should maintain momentum against a Houston defense without two of its top three corners, including their slot defender.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
The Colts' cornerback personnel is weak but their run defense is strong, setting up a feast for Calvin Ridley and the Jags passing game.
Rather than a concern, Trevon Diggs might be a target for Deebo Samuel on Sunday.
There's pressure on Keenan Allen to step up with Mike Williams out, and the Jaguars defense appears vulnerable in the slot.